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- Title
Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients.
- Authors
Ragin, Camille; Liu, Jeffrey C.; Jones, Gieira; Shoyele, Olubunmi; Sowunmi, Bukola; Kennett, Rachel; Gibbs, Denise; Blackman, Elizabeth; Esan, Michael; Brandwein, Margaret S.; Devarajan, Karthik; Bussu, Francesco; Chernock, Rebecca; Chih-Yen Chien; Cohen, Marc A.; El-Mofty, Samir; Mikio Suzuki; D'Souza, Gypsyamber; Funchain, Pauline; Eng, Charis
- Abstract
The landscape of human papillomavirus (HPV) infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P < 0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16,18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P < 0.0001). There was no statistically significant difference in HPV16,18 prevalence in nonoropharyngeal cancer by race (P = 0.682). With regard to the pattern of HPV16,18 status and p16 expression, White patients had the highest proportion of HPV16,18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0 and 22.6%, respectively) [P < 0.0001]. Our findings suggest that the pattern of HPV16,18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.
- Subjects
PAPILLOMAVIRUSES; HEAD &; neck cancer; META-analysis; GENEALOGY; ONCOGENIC DNA viruses
- Publication
Carcinogenesis, 2017, Vol 38, Issue 2, p218
- ISSN
0143-3334
- Publication type
Article
- DOI
10.1093/carcin/bgw203