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- Title
Re-positive testing, clinical evolution and clearance of infection: results from COVID-19 cases in isolation in Viet Nam.
- Authors
Ngoc-Anh Hoang; Thai Quang Pham; Ha-Linh Quach; Khanh Cong Nguyen; Colquhoun, Samantha; Lambert, Stephen; Duong Huy Luong; Quang Dai Tran; Dinh Cong Phung; Tran Nhu Duong; Nghia Duy Ngu; Tu Anh Tran; Hue Bich Thi Nguyen; Duc-Anh Dang; Vogt, Florian
- Abstract
Objective: Asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and test re-positivity after a negative test have raised concerns about the ability to effectively control the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the prevalence of COVID-19 asymptomatic and pre-symptomatic infections during the second wave of COVID-19 in Viet Nam, and to better understand the duration of SARS-CoV-2 infection and the dynamics between the evolution of clinical symptoms and SARS-CoV-2 test positivity among confirmed COVID-19 cases. Methods: We conducted a cohort analysis on the first 50 confirmed cases during the second COVID-19 wave in Viet Nam using clinical, laboratory and epidemiological data collected from 9 March to 30 April 2020. Kaplan-Meier estimates were used to assess time to clearance of SARS-CoV-2 infection, and log-rank tests were used to explore factors related to time to SARS-CoV-2 infection clearance. Results: Most cases (58%) had no typical signs or symptoms of COVID-19 at the time of diagnosis. Ten cases (20%) were re-positive for SARS-CoV-2 during infection. Eight cases (16%) experienced COVID-19 symptoms after testing negative for SARS-CoV-2. The median duration from symptom onset until clearance of infection was 14 days (range: 6–31); it was longer in re-positive and older patients and those with pre-existing conditions. Conclusion: Asymptomatic and pre-symptomatic infections were common during the second wave of COVID-19 in Viet Nam. Re-positivity was frequent during hospitalization and led to a long duration of SARS-CoV-2 infection.
- Subjects
VIETNAM; COVID-19; COVID-19 pandemic; CORONAVIRUS diseases; H7N9 Influenza
- Publication
Western Pacific Surveillance & Response Journal, 2021, Vol 12, Issue 4, p82
- ISSN
2094-7321
- Publication type
Article
- DOI
10.5365/wpsar.2021.12.4.857