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- Title
The Association Between Leucine and Diabetic Nephropathy in Different Gender: A Cross-Sectional Study in Chinese Patients With Type 2 Diabetes.
- Authors
Gao, Xiaoqian; Hou, Ruiqin; Li, Xin; Qiu, Xing-Hua; Luo, Hui-Huan; Liu, Sheng-Lin; Fang, Zhong-Ze
- Abstract
Objective: This study aimed to evaluate how leucine are associated with diabetic nephropathy (DN) in type 2 diabetes (T2D) patients and the gender difference of this association. Methods: We retrieved 1,031 consecutive patients with T2D who meet the inclusion and exclusion criteria from the same tertiary care center and extracted clinical information from electronic medical record. Plasma leucine was measured by liquid chromatography-mass spectrometer. Restricted cubic spline (RCS) was conducted to examine potential non-linear relationship between leucine and the risk of DN. Logistic regression was used to obtain odds ratio (OR) and confidence interval (CI). Additive interaction was used to estimate the interaction effect between leucine and gender for DN. Results: We found there was a negative correlation between leucine and the risk of DN. After stratifying all patients by gender, this relationship only remained significant in women (OR:0.57, CI:0.41–0.79). Conclusions: In conclusion, T2D patients with high levels of leucine have a lower risk of developing DN in female.
- Subjects
TYPE 2 diabetes; DIABETIC nephropathies; CHINESE people; LEUCINE; ELECTRONIC health records
- Publication
Frontiers in Endocrinology, 2021, Vol 11, pN.PAG
- ISSN
1664-2392
- Publication type
Article
- DOI
10.3389/fendo.2020.619422