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- Title
Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer.
- Authors
Minas, Tsion Zewdu; Candia, Julián; Dorsey, Tiffany H.; Baker, Francine; Tang, Wei; Kiely, Maeve; Smith, Cheryl J.; Zhang, Amy L.; Jordan, Symone V.; Obadi, Obadi M.; Ajao, Anuoluwapo; Tettey, Yao; Biritwum, Richard B.; Adjei, Andrew A.; Mensah, James E.; Hoover, Robert N.; Jenkins, Frank J.; Kittles, Rick; Hsing, Ann W.; Wang, Xin W.
- Abstract
There is evidence that tumor immunobiology and immunotherapy response may differ between African American and European American prostate cancer patients. Here, we determine if men of African descent harbor a unique systemic immune-oncological signature and measure 82 circulating proteins in almost 3000 Ghanaian, African American, and European American men. Protein signatures for suppression of tumor immunity and chemotaxis are elevated in men of West African ancestry. Importantly, the suppression of tumor immunity protein signature associates with metastatic and lethal prostate cancer, pointing to clinical importance. Moreover, two markers, pleiotrophin and TNFRSF9, predict poor disease survival specifically among African American men. These findings indicate that immune-oncology marker profiles differ between men of African and European descent. These differences may contribute to the disproportionate burden of lethal prostate cancer in men of African ancestry. The elevated peripheral suppression of tumor immunity may have important implication for guidance of cancer therapy which could particularly benefit African American patients. Ancestry-related differences in immunobiology may explain the health disparities observed in prostate cancer patients, with men of African origin bearing the highest prostate cancer burden. By measuring immune-related proteins in serum samples, here the authors report that systemic cytokines linked to suppression of tumor immunity are upregulated in men of African ancestry and associated with reduced survival.
- Subjects
AFRICAN American men; PROSTATE cancer; PROSTATE cancer patients; PROTEOMICS; AFRICAN Americans; CHEMOTAXIS; PROSTATE-specific antigen; CYTOTOXIC T cells
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-29235-2