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- Title
TLR-7 activation enhances IL-22–mediated colonization resistance against vancomycin-resistant enterococcus.
- Authors
Abt, Michael C.; Buffie, Charlie G.; Sušac, Bože; Becattini, Simone; Carter, Rebecca A.; Leiner, Ingrid; Keith, James W.; Artis, David; Osborne, Lisa C.; Pamer, Eric G.
- Abstract
The article presents a study on the correlation of murine norovirus infection with vancomycin-resistant Enterococcus faecium (VRE) reduced density in the intestinal tract of mice having antibiotic-induced loss of colonization resistance. The findings show that an orally bioavailable Toll-like receptor 7 (TLR-7) ligand which stimulates the intestine's innate immune pathways restores colonization resistance over an antibiotic-resistant bacterial pathogen.
- Subjects
NOROVIRUS diseases; ENTEROCOCCUS faecium; VANCOMYCIN; TOLL-like receptors; LABORATORY mice; THERAPEUTICS
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 327, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aad6663