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- Title
Folliculotropic Mycosis Fungoides with Skewed T-cell Receptor CDR3 Motif: Suggestive of Lipid-antigen Selection?
- Authors
MANTAKA, Panagiota; MALECKA, Agnieszka; TRØEN, Gunhild; HELSING, Per; GJERSVIK, Petter; BEISKE, Klaus; DELABIE, Jan
- Abstract
Folliculotropic mycosis fungoides (FMF), a variant of mycosis fungoides (MF) with distinct clinical features, is characterized by infiltration of malignant T cells in hair follicles. This raises the hypothesis that antigens in the hair follicle may contribute to the pathogenesis of FMF. T-cell receptor β gene (TRB) sequences as well as dendritic cell subsets in patients with FMF (n = 21) and control patients with MF (n = 20) were studied to explore this hypothesis. A recurrent usage of the TRB junctional genes TRBJ2-1 and TRBJ2-7 was found in patients with FMF compared with those with MF. These genes contribute to an amino acid motif in the complementarity- determining region 3 (CDR3) of the T-cell receptor. This motif was previously found in T cells stimulated by lipids bound to CD1 on antigen-presenting cells. Additional immunohistochemical analysis revealed abundant CD1c- and CD1a- expressing dendritic cells in FMF. The combined findings support a role for lipid-antigen selection in FMF.
- Subjects
MYCOSIS fungoides; T-cell receptor genes; T-cell lymphoma; HAIR follicle diseases; DERMATOLOGY
- Publication
Acta Dermato-Venereologica, 2017, Vol 97, Issue 9, p1081
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-2722