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- Title
TEMPO-Nanocellulose/Ca2+ Hydrogels: Ibuprofen Drug Diffusion and In Vitro Cytocompatibility.
- Authors
Fiorati, Andrea; Contessi Negrini, Nicola; Baschenis, Elena; Altomare, Lina; Faré, Silvia; Giacometti Schieroni, Alberto; Piovani, Daniele; Mendichi, Raniero; Ferro, Monica; Castiglione, Franca; Mele, Andrea; Punta, Carlo; Melone, Lucio
- Abstract
Stable hydrogels with tunable rheological properties were prepared by adding Ca2+ ions to aqueous dispersions of 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)-oxidized and ultra-sonicated cellulose nanofibers (TOUS-CNFs). The gelation occurred by interaction among polyvalent cations and the carboxylic units introduced on TOUS-CNFs during the oxidation process. Both dynamic viscosity values and pseudoplastic rheological behaviour increased by increasing the Ca2+ concentration, confirming the cross-linking action of the bivalent cation. The hydrogels were proved to be suitable controlled release systems by measuring the diffusion coefficient of a drug model (ibuprofen, IB) by high-resolution magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy. IB was used both as free molecule and as a 1:1 pre-formed complex with β-cyclodextrin (IB/β-CD), showing in this latter case a lower diffusion coefficient. Finally, the cytocompatibility of the TOUS-CNFs/Ca2+ hydrogels was demonstrated in vitro by indirect and direct tests conducted on a L929 murine fibroblast cell line, achieving a percentage number of viable cells after 7 days higher than 70%.
- Subjects
MAGIC angle spinning; HYDROGELS; DIFFUSION; NUCLEAR magnetic resonance; DYNAMIC viscosity; IBUPROFEN; DIFFUSION coefficients
- Publication
Materials (1996-1944), 2020, Vol 13, Issue 1, p183
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma13010183