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- Title
Clinical manifestations of chronic inflammatory demyelinating polyneuropathy with anti-cardiolipin antibodies.
- Authors
Nakajima, H.; Shinoda, K.; Doi, Y.; Tagami, M.; Furutama, D.; Sugino, M.; Kimura, F.; Hanafusa, T.
- Abstract
Nakajima H, Shinoda K, Doi Y, Tagami M, Furutama D, Sugino M, Kimura F, Hanafusa T. Clinical manifestations of chronic inflammatory demyelinating polyneuropathy with anti-cardiolipin antibodies.Acta Neurol Scand 2005 DOI: 10.1111/j.1600-0404.2005.00387.x© Blackwell Munksgaard 2005.Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune syndrome where certain autoantibodies define clinicopathologic subgroups. In the present study, serum anti-cardiolipin antibodies (aCL) were evaluated.We investigated aCL in sera from 21 patients diagnosed with CIDP in our hospital between 1991 and 2001. The four CIDP patients with aCL (aCL+) were compared with 17 patients without aCL (aCL−).All aCL+ patients displayed sensory-motor polyneuropathy, with severity and distribution of weakness resembling those in aCL− patients. Anti-nuclear antibody titer of aCL+ patients were significantly higher than those in aCL− patients. None of aCL+ patients presented clinical manifestations of primary anti-phospholipid syndrome (APS), such as thromboses or recurrent abortion. Although the aCL+ patients were older and had more complications and more severe pathologic features than aCL− patients, they responded well to steroid pulse or intravenous immunoglobulin.The aCL in CIDP apparently differ from‘autoimmune’ aCL in APS, instead being among the autoantibodies pathologically involved in CIDP subgroups.
- Subjects
CARDIOLIPIN; IMMUNOGLOBULINS; PROTEIN C deficiency; BLOOD coagulation; CARDIOVASCULAR diseases; BIRTH control
- Publication
Acta Neurologica Scandinavica, 2005, Vol 111, Issue 4, p258
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1111/j.1600-0404.2005.00387.x