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- Title
Age-stratified heritability estimation in the Framingham Heart Study families.
- Authors
Brown, W. Mark; Beck, Stephanie R.; Lange, Ethan M.; Davis, Cralen C.; Kay, Christine M.; Langefeld, Carl D.; Rich, Stephen S.
- Abstract
The Framingham Heart Study provides a unique source of longitudinal family data related to CVD risk factors. Age-stratified heritability estimates were obtained over three age groups (31-49 years, 50-60 years, and 61-79 years), reflecting the longitudinal nature of the data, for four quantitative traits. Age-adjusted heritability estimates were obtained at a single common time point for the same four quantitative traits. The importance of these groups is that they consist of the same individuals. The highest age-stratified heritability estimate (h² = 0.88 (± 0.06)) was for height in the model adjusting for gender over all three age groups. SBP gave the lowest heritability estimate (h² = 0.15 (± 0.11)) for the 70 age group in the model adjusting for gender, height, BMI, smoker, and drinker. BMI had slightly higher estimates (h² = 0.64 (± 0.11)) in the 40 age group than previously published. The highest age-adjusted heritability estimate (h² = 0.90 (± 0.06)) was for height in the model adjusting for gender. SBP gave the lowest heritability estimate (h² = 0.38 (± 0.09)) for unadjusted model. These results indicate that some common, complex traits may vary little in their genetic architecture over time and suggest that a common set of genes may be contributing to observed variation for these longitudinally collected phenotypes.
- Subjects
CARDIOVASCULAR diseases; CARDIOVASCULAR diseases risk factors; FRAMINGHAM Heart Study (Organization); AGE groups; HEREDITY
- Publication
BMC Genetics, 2003, Vol 4, pS32
- ISSN
1471-2156
- Publication type
Article
- DOI
10.1186/1471-2156-4-S1-S32