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- Title
Moxifloxacin and gemifloxacin mediates its antispasmodic profile via ATP-sensitive potassium channels: An in-vitro bioassay study.
- Authors
Abidullah; Ahmad, Shujaat; Ali, Niaz; Almarshad, Feras; Nabi, Muhammad; Ur Rahman, Shafiq; Ullah, Shakir; Khan, Jahangir; Hussain, Haya; Bukhari, Syeda Hajira
- Abstract
Moxifloxacin and gemifloxacin were tested on isolated rabbits' jejunal preparations as little is known about its effects on gastrointestinal tissues. Moxifloxacin and gemifloxacin were tested in concentrations 0.01-10µg/mL for possible effect(s) on isolated rabbits' jejunal preparations. The drugs were applied on spontaneous, on low K+ (20mM)-induced contractions and on high K+ (80mM)-induced contractions. Response was plotted as % of its respective controls. EC50 for Moxifloxacin and Gemifloxacin on spontaneous (without Glibenclamide) contractions are 2.83±0.5µg/mL and 1.11±0.2µg/mL, respectively. Moxifloxacin and Gemifloxacin relaxed the low K+ (20mM) -induced contractions, which were inhibited in presence of Glibenclamide (3µM). Our result indicates that the relaxant activity of Moxifloxacin and Gemifloxacin is mediated possibly through activation of ATP-sensitive potassium channels (KATP). The relaxant effect of Moxifloxacin and Gemifloxacin is predominantly mediated by activation of ATP-Sensitive potassium channels (KATP), which could be cause of one of relaxing mechanisms.
- Subjects
POTASSIUM channels; MOXIFLOXACIN; BIOLOGICAL assay; GLIBENCLAMIDE
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2021, Vol 34, p1983
- ISSN
1011-601X
- Publication type
Article
- DOI
10.36721/PJPS.2021.34.5.SUP.1983-1988.1