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- Title
Comparative biological assessments of endodontic root canal sealer containing surface pre-reacted glass-ionomer (S-PRG) filler or silica filler.
- Authors
Hirofumi MIYAJI; Kayoko MAYUMI; Saori MIYATA; Erika NISHIDA; Kanako SHITOMI; Asako HAMAMOTO; Saori TANAKA; Tsukasa AKASAKA
- Abstract
Surface pre-reacted glass-ionomer (S-PRG) filler releases several ions, such as fluoride, borate and strontium ions, to exert bioactive effects. We fabricated an endodontic root canal sealer containing S-PRG fillers (S-PRG sealer) and then evaluated the antibacterial and anti-inflammatory properties of S-PRG sealer compared with sealer containing conventional silica fillers (silica sealer). Antibacterial tests showed that S-PRG sealer significantly reduced the turbidity of Enterococcus faecalis compared with silica sealer. Implantation of S-PRG or silica sealer blocks in rat subcutaneous tissue showed that S-PRG sealer decreased the proinflammatory response compared with silica sealer at 10 days post-implantation. In addition, immunostaining revealed that infiltration of CD68- and peroxidase-positive cells around the S-PRG sealer was significantly lower than that in silica sealer. Therefore, it was suggested that S-PRG sealer exhibits antibacterial and anti-inflammatory effects.
- Subjects
SURFACE sealers; ROOT canal treatment; STRONTIUM ions; SILICA; ENTEROCOCCUS faecalis
- Publication
Dental Materials Journal, 2020, Vol 39, Issue 2, p287
- ISSN
0287-4547
- Publication type
Article
- DOI
10.4012/dmj.2019-029