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- Title
Increased levels of plasma thrombomodulin are associated with vascular and all-cause mortality in patients on long-term anticoagulant treatment.
- Authors
Jansson, J.-H.; Boman, K.; Brännström, M.; Nilsson, T. K.
- Abstract
Background The aim of the study was to test if plasma levels of thrombomodulin could predict mortality in 209 patients on long-term anticoagulant treatment followed up for 38 years. Methods and Results The thrombomodulin level was 60·9 ± 29·8 μg. 1−1 for all 45 patients who died and 60·5 ± 30·5 .μg. 1−1 for the 38 vascular deaths, compared to 52·3 ± 20·7 μg. 1−1 for the 164 survivors. We found that, in Cox regression analyses, all-cause (P=0·025) and vascular mortality (P=0·042) was significantly and independently associated with increased levels of thrombomodulin. Conclusions The level of plasma thrombomodulin can predict all-cause and vascular mortality in patients on long-term anticoagulant treatment.
- Publication
European Heart Journal, 1996, Vol 17, Issue 10, p1503
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/oxfordjournals.eurheartj.a014713