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- Title
ESI-MS studies of the non-covalent interactions between biologically important metal ions and N-sulfonylcytosine derivatives.
- Authors
Ključarić, Valentina; Kobetić, Renata; Rinkovec, Jasmina; Kazazić, Snježana; Gembarovski, Dubravka; Saftić, Dijana; Matić, Josipa; Ban, Željka; Žinić, Biserka
- Abstract
The aim of this report is to present the electrospray ionization mass spectrometry results of the non-covalent interaction of two biologically active ligands, N-1-(p-toluenesulfonyl)cytosine, 1-TsC, 1 and N-1-methanesulfonylcytosine, 1-MsC, 2 and their Cu(II) complexes Cu(1-TsC-N3)2Cl2, 3 and Cu(1-MsC-N3)2Cl2 and 4 with biologically important cations: Na+, K+, Ca2+, Mg2+ and Zn2+. The formation of various complex metal ions was observed. The alkali metals Na+ and K+ formed clusters because of electrostatic interactions. Ca2+ and Mg2+ salts produced the tris ligand and mixed ligand complexes. The interaction of Zn2+ with 1–4 produced monometal and dimetal Zn2+ complexes as a result of the affinity of Zn2+ ions toward both O and N atoms.
- Subjects
ELECTROSTATIC interaction; ELECTROSPRAY ionization mass spectrometry; COPPER compounds; SODIUM ions; POTASSIUM ions; CALCIUM ions; MAGNESIUM ions; ZINC ions
- Publication
Journal of Mass Spectrometry, 2016, Vol 51, Issue 11, p998
- ISSN
1076-5174
- Publication type
Article
- DOI
10.1002/jms.3810