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- Title
Development of anticancer agents targeting the Hedgehog signaling.
- Authors
Zhang, Xiangqian; Tian, Ye; Yang, Yanling; Hao, Jijun
- Abstract
Hedgehog signaling is an evolutionarily conserved pathway which is essential in embryonic and postnatal development as well as adult organ homeostasis. Abnormal regulation of Hedgehog signaling is implicated in many diseases including cancer. Consequently, substantial efforts have made in the past to develop potential therapeutic agents that specifically target the Hedgehog signaling for cancer treatment. Here, we review the therapeutic agents for inhibition of the Hedgehog signaling and their clinical advances in cancer treatment.
- Subjects
HOMEOSTASIS; CANCER; HEDGEHOG signaling proteins; CANCER treatment; DISEASES
- Publication
Cellular & Molecular Life Sciences, 2017, Vol 74, Issue 15, p2773
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-017-2497-x