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- Title
Differential usage of T-cell receptor Vβ gene families by CD4<sup>+</sup> and CD8<sup>+</sup> T cells in patients with CD8<sup>hi</sup> common variable immunodeficiency: evidence of a post-thymic effect.
- Authors
Duchmann, R.; Jaffe, J.; Ehrhardt, R.; Alling, D. W.; Strober, W.
- Abstract
In this study, we report that differences between T-cell receptor (TCR) Vβ gene family usage in CD4+ and CD8+ T cells are significantly greater in a subgroup of patients with common variable immanodeficiency (CVI) and high levels of activated CD8+ T cells (CD8hi CVI) than in controls (P < 0·001). In CD8hi CVI patients, such differences were also significantly greater for Vβ12 than for other Vβ families. As the causes of the differential usage of Vβ gene families by CD4+ and CD8+ T cells are under investigation, it was interesting that the combined differences between Vβ gene family usage in the CD4+ and CD8+ T-cell subpopulations as a whole were significantly lower than the combined differences between individual Vβ gene family usage in either CD4+ or CD8+ T-cell subpopulations (P < 0·001 in both control and CD8hi CVI patients). Further, the pattern of Vβ gene family usage in CD4+ T cells was remarkably similar to that in CD8+ T cells in both groups. These data strongly suggest that differences in Vβ gene family usage arising from co-selection by major histocompatibility complex (MHC) class I versus MHC class II restriction elements do not fundamentally distort ‘basic’ Vβ gene family usage patterns. They also support the concept that differences in CD4+ and CD8+ T-cell Vβ gene family usage, which were increased in CD8hi CVI, can arise from high-affinity interactions between disease-associated antigens or superantigens and T cells in the post-thymic T-cell compartment.
- Subjects
T-cell receptor genes; GENES; T cell receptors; T cells; IMMUNODEFICIENCY; IMMUNITY
- Publication
Immunology, 1996, Vol 87, Issue 1, p99
- ISSN
0019-2805
- Publication type
Article