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- Title
IL-10 enhances expression of the IL-2 receptor α chain on T cells.
- Authors
Cohen, S. B. A.; Katsikis, P. D.; Feldmann, M.; Londei, M.
- Abstract
Interleukin-10 (IL-10) has various immunomodulatory actions depending on the target cell type. Some of these effects have been shown to be owing to its ability to down-regulate surface expression of markers, for example HLA-DR on macrophages and CD25 (IL-2 receptor α chain) on B cells. In this report we show that preincubation of IL-10 for 24 hr up-regulates expression of the activation marker CD25, but not HLA-DR on cloned T cells of various phenotypes such as CD4+, CD8+, CD4- CD8- αβ and γδ T-cell receptor (TCR)-expressing cells. This up-regulation of CD25 was accompanied by an increase in the T cells IL-2-dependent proliferative response in 63% of the CE4+ clones and 100% of the CD8+, CD4-, CD8- αβ and γδ TCR+ clones analysed. IL-10 was also shown to be at least partly responsible for the up-regulation of CD25 on mitogen-activated peripheral blood mononuclear cells, suggesting that IL-10 has this CD25 modulatory effect within a more physiological environment. Our data suggest that IL-10 can have a multitude of effects on human T cells, and should not be considered exclusively as an immunoinhibitory cytokine.
- Subjects
INTERLEUKIN-10; HLA histocompatibility antigens; INTERLEUKINS; B cells; T cells; IMMUNOLOGY; MEDICAL sciences
- Publication
Immunology, 1994, Vol 83, Issue 3, p329
- ISSN
0019-2805
- Publication type
Article