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- Title
Persistent apparent pancreatic β-cell defects in premenarchal PCOS relatives.
- Authors
Torchen, Laura C; Fogel, Naomi R; Brickman, Wendy J; Paparodis, Rodis; Dunaif, Andrea
- Abstract
<bold>Context: </bold>Polycystic ovary syndrome confers an increased risk for type 2 diabetes in affected women as early as adolescence. First-degree relatives (FDRs) of affected women are at increased risk for associated reproductive and metabolic phenotypes.<bold>Objective: </bold>We sought to prospectively assess insulin sensitivity and secretion and to measure reproductive hormone levels using sensitive techniques.<bold>Design, Setting, and Participants: </bold>Twelve premenarchal FDR girls and 10 control girls of comparable age, Tanner stage, and body mass index were studied at an academic medical center.<bold>Interventions: </bold>Frequently sampled intravenous glucose tolerance tests and oral glucose tolerance tests were performed.<bold>Main Outcome Measures: </bold>Reproductive hormone levels, lipid profiles, glucose tolerance, and frequently sampled iv glucose tolerance test parameters of insulin sensitivity and secretion were investigated.<bold>Results: </bold>Disposition index (DI), insulin secretion corrected for insulin sensitivity, was decreased in FDR compared with control girls at baseline (P = .01), independent of dysglycemia. Decreases in DI persisted in FDR girls during the 2-year follow-up (P = .003). T levels were increased (P = .02) in FDR compared with control girls at baseline, but this difference did not persist because T levels increased in control girls.<bold>Conclusions: </bold>DI is decreased in peripubertal FDR girls, and this decrease persists as puberty progresses. These findings suggest that β-cell dysfunction is an early defect in glucose homeostasis preceding decompensation in glucose tolerance in FDR girls. T levels were increased in FDR girls earlier than previously reported, but these changes did not persist, suggesting an earlier onset of pubertal increases in glandular androgen secretion in FDR girls.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2014, Vol 99, Issue 10, p3855
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2014-1474