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- Title
Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate.
- Authors
Andronesi, Ovidiu C.; Rapalino, Otto; Gerstner, Elizabeth; Chi, Andrew; Batchelor, Tracy T.; Cahill, Dan P.; Sorensen, A. Gregory; Rosen, Bruce R.
- Abstract
The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the production of D-2-hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels of this metabolite may play a central role in propagating downstream the effects of mutant IDH, leading to malignant transformation of cells. Hence, D-2HG may be an ideal biomarker for both diagnosing and monitoring treatment response targeting IDH mutations. Magnetic resonance spectroscopy (MRS) is well suited to the task of noninvasive D-2HG detection, and there has been much interest in developing such methods. Here, we review recent efforts to translate methodology using MRS to reliably measure in vivo D-2HG into clinical research.
- Subjects
GENETIC mutation; NUCLEAR magnetic resonance spectroscopy; NUCLEAR spectroscopy; BIOCHEMISTRY; CANCER cells; CELL transformation
- Publication
Journal of Clinical Investigation, 2013, Vol 123, Issue 9, p3659
- ISSN
0021-9738
- Publication type
Article
- DOI
10.1172/JCI67229