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- Title
Growth hormone enhances thymic function in HIV-1-infected adults.
- Authors
Napolitano, Laura A.; Schmidt, Diane; Gotway, Michael B.; Ameli, Niloufar; Filbert, Erin L.; Ng, Myra M.; Clor, Julie L.; Epling, Lorrie; Sinclair, Elizabeth; Baum, Paul D.; Kai Li; Killian, Marisela Lua; Bacchetti, Peter; McCune, Joseph M.; Li, Kai
- Abstract
Growth hormone (GH) is an underappreciated but important regulator of T cell development that can reverse age-related declines in thymopoiesis in rodents. Here, we report findings of a prospective randomized study examining the effects of GH on the immune system of HIV-1-infected adults. GH treatment was associated with increased thymic mass. In addition, GH treatment enhanced thymic output, as measured by both the frequency of T cell receptor rearrangement excision circles in circulating T cells and the numbers of circulating naive and total CD4(+) T cells. These findings provide compelling evidence that GH induces de novo T cell production and may, accordingly, facilitate CD4(+) T cell recovery in HIV-1-infected adults. Further, these randomized, prospective data have shown that thymic involution can be pharmacologically reversed in humans, suggesting that immune-based therapies could be used to enhance thymopoiesis in immunodeficient individuals.
- Subjects
SOMATOTROPIN; T cells; HIV-positive persons; LABORATORY rodents; IMMUNE system; AIDS; COMPARATIVE studies; CROSSOVER trials; HEMATOPOIESIS; HIV; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; SOMATOMEDIN; THYMUS; EVALUATION research; HUMAN growth hormone; RANDOMIZED controlled trials; CD4 lymphocyte count; THERAPEUTICS
- Publication
Journal of Clinical Investigation, 2008, Vol 118, Issue 3, p1085
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI32830