We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Photoinduced Thiol-ene Chemistry Applied to the Synthesis of Self-Assembling Elastin-Inspired Glycopeptides.
- Authors
Piccirillo, Germano; Pepe, Antonietta; Bedini, Emiliano; Bochicchio, Brigida
- Abstract
Synthetic (glyco)peptides inspired by proteins able to self-assemble are appealing biomaterials in the field of tissue engineering and regenerative medicine. Herein, for the first time, taking advantage of thiol-ene chemistry coupled to solid-phase peptide synthesis, a self-assembling peptide inspired by elastin protein was bioconjugated to three carbohydrates in order to obtain the corresponding glycopeptides. They were studied at the molecular and supramolecular level. The results show that the carbohydrate influences the molecular conformation of the glycopeptide and its self-aggregation properties as well. As future perspective, the results could enable us to tune the final self-aggregation properties of the glycopeptide by changing the sugar moiety.
- Subjects
GLYCOPEPTIDE synthesis; THIOL derivatives; MOLECULAR self-assembly; MOLECULAR conformation; BIOMATERIALS; PEPTIDE synthesis; ELASTIN; BIOCONJUGATES
- Publication
Chemistry - A European Journal, 2017, Vol 23, Issue 11, p2648
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201604831