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- Title
Tailoring broadband inversion pulses for MAS Solid state NMR.
- Authors
Riedel, Kerstin; Herbst, Christian; Leppert, Jörg; Ohlenschläger, Oliver; Görlach, Matthias; Ramachandran, Ramadurai
- Abstract
A simple approach is demonstrated for designing optimised broadband inversion pulses for MAS solid state NMR studies of biological systems. The method involves a two step numerical optimisation procedure and takes into account experimental requirements such as the pulse length, resonance offset range and extent of H1 inhomogeneity compensation needed. A simulated annealing protocol is used initially to find appropriate values for the parameters that define the well known tanh/tan adiabatic pulse such that a satisfactory spin inversion is achieved with minimum RF field strength. This information is then used in the subsequent stage of refinement where the RF pulse characteristics are further tailored via a local optimisation procedure without imposing any restrictions on the amplitude and frequency modulation profiles. We demonstrate that this approach constitutes a generally applicable tool for obtaining pulses with good inversion characteristics. At moderate MAS frequencies the efficacy of the method is experimentally demonstrated for generating double-quantum NMR spectra via the zero-quantum dipolar recoupling scheme RFDR.
- Subjects
NUCLEAR magnetic resonance; SOLID state physics; NUCLEAR magnetic resonance spectroscopy; BIOLOGICAL systems; SPECTRUM analysis
- Publication
Journal of Biomolecular NMR, 2006, Vol 35, Issue 4, p275
- ISSN
0925-2738
- Publication type
Article
- DOI
10.1007/s10858-006-9044-7