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- Title
Effect of thyroid peroxidase antibodies on thyroid-stimulating hormone reference limits in a primarily Latina population.
- Authors
Lee, Richard H.; Spencer, Carole A.; Montoro, Martin N.; Aghajanian, Paola; Goodwin, T. Murphy; Miller, Erin A.; Petrovic, Ivana; Braverman, Lewis E.; Mestman, Jorge H.
- Abstract
The aim of the paper is to determine the prevalence of thyroid peroxidase antibodies (TPOAb) and assess its effect on the thyroid-stimulating hormone (TSH) reference range during pregnancy in a primarily Latina population. Serum samples were collected from healthy pregnant women and non-pregnant controls. TSH reference ranges were calculated when TPOAb-positive patients were either included or excluded. A total of 134 pregnant women and 107 non-pregnant controls were recruited. Positive TPOAb titres were found in 23 (17.2%) of the 134 pregnant women, and in 14 (13.1%) of the 107 non-pregnant controls. When the TPOAb-positive women were included in the TSH analysis, the upper reference limit using two different methods was consistently higher: 0-2.2 fold in the non-pregnant women, 2.01-2.78 fold in the first trimester, 3.18-4.7 fold in the second and 1.05-1.42 fold in the third. The lower TSH reference limit was not affected by the inclusion of TPOAb-positive subjects. In conclusion, inclusion of TPOAb-positive patients results in higher upper reference limits during pregnancy.
- Subjects
IMMUNOGLOBULINS; IODIDE peroxidase; THYROTROPIN; PREGNANT women; DISEASE prevalence; MOTHERS; FIRST trimester of pregnancy; SECOND trimester of pregnancy; THIRD trimester of pregnancy; PHYSIOLOGY
- Publication
Obstetric Medicine (1753-495X), 2009, Vol 2, Issue 4, p154
- ISSN
1753-495X
- Publication type
Article
- DOI
10.1258/om.2009.090039