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- Title
Bilateral gonadoblastoma producing steroid hormones in a patient with 45,X/46,XY gonadal dysgenesis.
- Authors
Fukamatsu, Yoshihito; Tsukahara, Yoshiharu; Hayashi, Seiichi; Yoshikawa, Fumihiko; Fukuta, Toru; Fukamatsu, Y; Tsukahara, Y; Hayashi, S; Yoshikawa, F; Fukuta, T
- Abstract
A case of bilateral gonadoblastoma in a phenotypic female with 45,X/46,XY gonadal dysgenesis is presented. Hormonal investigations revealed that serum testosterone, estradiol and beta-human chorionic gonadotropin decreased following excision of the tumors, but follicle-stimulating hormone and luteinizing homrone levels increased further. Immunohistochemical staining for testosterone and estradiol was positive in both Leydig and lutein-like cells in the tumor. It is suggested that gonadoblastoma is capable of producing testosterone and estradiol, and Leydig or lutein-like cells may be the actual source of these steroid hormones.
- Publication
Gynecologic & Obstetric Investigation, 1990, Vol 30, Issue 3, p189
- ISSN
0378-7346
- Publication type
journal article
- DOI
10.1159/000293266