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- Title
PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats.
- Authors
Balasse, Laure; Maerk, Julia; Pain, Frédéric; Genoux, Aurelie; Fieux, Sylvain; Lefebvre, Françoise; Morel, Christian; Gisquet-Verrier, Pascale; Laníece, Philippe; Zimmer, Luc
- Abstract
The aim of this study was to demonstrate the potential of a wireless pixelated ß+-sensitive intracerebral probe (PIXSIC) for in vivo positron emission tomographic (PET) radiopharmacology in awake and freely moving rodents. The binding of [11C]raclopride to D2 dopamine receptors was measured in anesthetized and awake rats following injection of the radiotracer. Competitive binding was assessed with a cold raclopride injection 20 minutes later. The device can accurately monitor binding of PET ligands in freely moving rodents with a high spatiotemporal resolution. Reproducible time-activity curves were obtained for pixels throughout the striatum and cerebellum. A significantly lower [11C]raclopride tracer-specific binding was observed in awake animals. These first results pave the way for PET tracer pharmacokinetics measurements in freely moving rodents.
- Subjects
CEREBELLUM; RADIATION-sensitizing agents; LABORATORY rats; PHARMACOKINETICS; RADIOPHARMACOLOGY
- Publication
Molecular Imaging, 2015, Vol 14, p484
- ISSN
1535-3508
- Publication type
Article
- DOI
10.2310/7290.2015.00020