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- Title
A Fatal Case of Neuroblastoma Complicated by Posterior Reversible Encephalopathy with Rapidly Evolving Transplantation-Associated Thrombotic Microangiopathy.
- Authors
Matsui, Motohiro; Makimoto, Atsushi; Saito, Yuya; Enokizono, Mikako; Matsuoka, Kentaro; Yuza, Yuki
- Abstract
Background: Transplantation-associated thrombotic microangiopathy (TA-TMA) is a severe complication of hematopoietic stem cell transplantation and is sometimes fatal. Observations: A 4-year-old, male patient with stage M neuroblastoma (NBL) who had received an allogeneic bone marrow transplantation (BMT) from his sibling five months previously presented with rapidly progressive posterior reversible encephalopathy (PRES) complicated with TA-TMA. Although the patient was transferred to the pediatric intensive care unit, he died within one week after the onset of the latest symptoms. Conclusions: This is the first description of a fatal case of NBL complicated by PRES with rapidly evolving TA-TMA after an allogenic BMT.
- Subjects
DISEASE progression; INTENSIVE care units; NEUROBLASTOMA; BONE marrow transplantation; PEDIATRICS; TUMOR classification; SYMPTOMS; POSTERIOR leukoencephalopathy syndrome; HEMATOPOIETIC stem cell transplantation; THROMBOCYTOPENIA; HEMOLYTIC-uremic syndrome; DISEASE complications
- Publication
Children, 2023, Vol 10, Issue 3, p506
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children10030506