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- Title
CD8<sup>+</sup> T cell development: CD4 to the rescue.
- Authors
MacDonald, H. Robson; Held, Werner
- Abstract
Focuses on the development of CD8[sup +] (cytotoxic) T cells. Controversy over how immature CD4[sup +]CD8[sup 8] thymocytes become committed to either the CD4 (helper) or CD8 lineage; Genetic ablation of a silencer element in the gene encoding CD4; Lineage commitment occurring via a stochastic, rather than instructive, mechanism.
- Subjects
T cells; ABLATIVE materials; GENETICS
- Publication
Nature Immunology, 2001, Vol 2, Issue 12, p1091
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1201-1091