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- Title
Asymptomatic syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following duloxetine treatment for pain with depression: Two case reports.
- Authors
Sato, Aoi; Yasui‐Furukori, Norio; Oda, Yumiko; Yang, Misa; Suzuki, Yudai; Shinozaki, Masataka; Shimizu, Taro; Shimoda, Kazutaka
- Abstract
Background: Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a common side effect in patients treated with SSRIs and venlafaxine, while there is little information on SIADH in the treatment of duloxetine for pain. Case presentation: The patients were an 83‐year‐old Japanese male and a 71‐year‐old Japanese female. Several years earlier, they complained of pain. Accidentally, blood tests revealed hyponatremia of 110 mmol/L and 108 mmol/L 35 days and 40 days after initiating duloxetine 20 mg/day, respectively. The hyponatremia of both patients recovered after switching from duloxetine to mianserin. Conclusion: We conclude that asymptomatic SIADH was induced by use of duloxetine. Psychiatrists should be aware of this syndrome.
- Publication
Neuropsychopharmacology Reports, 2022, Vol 42, Issue 3, p387
- ISSN
2574-173X
- Publication type
Article
- DOI
10.1002/npr2.12279