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Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods.
Published in:
Frontiers in Pharmacology, 2022, v. 13, p. 01, doi. 10.3389/fphar.2022.980747
By:
- Nicolas, Chantel I.;
- Linakis, Matthew W.;
- Minto, Melyssa S.;
- Mansouri, Kamel;
- Clewell, Rebecca A.;
- Miyoung Yoon;
- Wambaugh, John F.;
- Patlewicz, Grace;
- McMullen, Patrick D.;
- Andersen, Melvin E.;
- Clewell III, Harvey J.
Publication type:
Article
Simulating Quantitative Cellular Responses Using Asynchronous Threshold Boolean Network Ensembles.
Published in:
BMC Systems Biology, 2011, v. 5, n. 1, p. 109, doi. 10.1186/1752-0509-5-109
By:
- Jack, John;
- Wambaugh, John F.;
- Shah, Imran
Publication type:
Article
In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity.
Published in:
Archives of Toxicology, 2023, v. 97, n. 6, p. 1701, doi. 10.1007/s00204-023-03490-8
By:
- Müller, Fabrice A.;
- Stamou, Marianna;
- Englert, Felix H.;
- Frenzel, Ole;
- Diedrich, Sabine;
- Suter-Dick, Laura;
- Wambaugh, John F.;
- Sturla, Shana J.
Publication type:
Article
Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals.
Published in:
Scientific Data, 2020, v. 7, n. 1, p. 1, doi. 10.1038/s41597-020-0455-1
By:
- Sayre, Risa R.;
- Wambaugh, John F.;
- Grulke, Christopher M.
Publication type:
Article
In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories.
Published in:
Toxics, 2024, v. 12, n. 9, p. 672, doi. 10.3390/toxics12090672
By:
- Crizer, David M.;
- Rice, Julie R.;
- Smeltz, Marci G.;
- Lavrich, Katelyn S.;
- Ravindra, Krishna;
- Wambaugh, John F.;
- DeVito, Michael;
- Wetmore, Barbara A.
Publication type:
Article
A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS).
Published in:
Toxics, 2024, v. 12, n. 4, p. 271, doi. 10.3390/toxics12040271
By:
- Judson, Richard S.;
- Smith, Doris;
- DeVito, Michael;
- Wambaugh, John F.;
- Wetmore, Barbara A.;
- Paul Friedman, Katie;
- Patlewicz, Grace;
- Thomas, Russell S.;
- Sayre, Risa R.;
- Olker, Jennifer H.;
- Degitz, Sigmund;
- Padilla, Stephanie;
- Harrill, Joshua A.;
- Shafer, Timothy;
- Carstens, Kelly E.
Publication type:
Article
Category-Based Toxicokinetic Evaluations of Data-Poor Per- and Polyfluoroalkyl Substances (PFAS) using Gas Chromatography Coupled with Mass Spectrometry.
Published in:
Toxics, 2023, v. 11, n. 5, p. 463, doi. 10.3390/toxics11050463
By:
- Kreutz, Anna;
- Clifton, Matthew S.;
- Henderson, W. Matthew;
- Smeltz, Marci G.;
- Phillips, Matthew;
- Wambaugh, John F.;
- Wetmore, Barbara A.
Publication type:
Article
A Machine Learning Model to Estimate Toxicokinetic Half-Lives of Per- and Polyfluoro-Alkyl Substances (PFAS) in Multiple Species.
Published in:
Toxics, 2023, v. 11, n. 2, p. 98, doi. 10.3390/toxics11020098
By:
- Dawson, Daniel E.;
- Lau, Christopher;
- Pradeep, Prachi;
- Sayre, Risa R.;
- Judson, Richard S.;
- Tornero-Velez, Rogelio;
- Wambaugh, John F.
Publication type:
Article
A Method for Identifying Prevalent Chemical Combinations in the U.S. Population.
Published in:
Environmental Health Perspectives, 2017, v. 125, n. 8, p. 1, doi. 10.1289/EHP1265
By:
- Kapraun, Dustin F.;
- Wambaugh, John F.;
- Ring, Caroline L.;
- Tornero-Velez, Rogelio;
- Setzer, R. Woodrow
Publication type:
Article
Computational Exposure Science: An Emerging Discipline to Support 21st-Century Risk Assessment.
Published in:
Environmental Health Perspectives, 2016, v. 124, n. 6, p. 697, doi. 10.1289/ehp.1509748
By:
- Egeghy, Peter P.;
- Sheldon, Linda S.;
- Isaacs, Kristin K.;
- Özkaynak, Halûk;
- Goldsmith, Michael-Rock;
- Wambaugh, John F.;
- Judson, Richard S.;
- Buckley, Timothy J.
Publication type:
Article
Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data.
Published in:
Environmental Health Perspectives, 2024, v. 132, n. 1, p. 017009-1, doi. 10.1289/EHP12188
By:
- Stanfield, Zachary;
- Setzer, R. Woodrow;
- Hull, Victoria;
- Sayre, Risa R.;
- Isaacs, Kristin K.;
- Wambaugh, John F.
Publication type:
Article
Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice.
Published in:
Toxicological Sciences, 2009, v. 107, n. 2, p. 331, doi. 10.1093/toxsci/kfn234
By:
- Inchio Lou;
- John F. Wambaugh;
- Christopher Lau;
- Roger G. Hanson;
- Andrew B. Lindstrom;
- Mark J. Strynar;
- R. Dan Zehr;
- R. Woodrow Setzer;
- Hugh A. Barton
Publication type:
Article
A regression analysis using simple descriptors for multiple dermal datasets: Going from individual membranes to the full skin.
Published in:
Journal of Applied Toxicology, 2023, v. 43, n. 6, p. 940, doi. 10.1002/jat.4435
By:
- Evans, Marina V.;
- Moxon, Thomas E.;
- Lian, Guoping;
- Deacon, Benjamin N.;
- Chen, Tao;
- Adams, Linda D.;
- Meade, Annabel;
- Wambaugh, John F.
Publication type:
Article
A Liver-Centric Multiscale Modeling Framework for Xenobiotics.
Published in:
PLoS ONE, 2016, v. 11, n. 9, p. 1, doi. 10.1371/journal.pone.0162428
By:
- Sluka, James P.;
- Fu, Xiao;
- Swat, Maciej;
- Belmonte, Julio M.;
- Cosmanescu, Alin;
- Clendenon, Sherry G.;
- Wambaugh, John F.;
- Glazier, James A.
Publication type:
Article
New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing.
Published in:
International Journal of Environmental Research & Public Health, 2020, v. 17, n. 6, p. 2124, doi. 10.3390/ijerph17062124
By:
- Zavala, Jose;
- Freedman, Anastasia N.;
- Szilagyi, John T.;
- Jaspers, Ilona;
- Wambaugh, John F.;
- Higuchi, Mark;
- Rager, Julia E.
Publication type:
Article
Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions.
Published in:
PLoS ONE, 2019, v. 14, n. 5, p. 1, doi. 10.1371/journal.pone.0217564
By:
- Honda, Gregory S.;
- Pearce, Robert G.;
- Pham, Ly L.;
- Setzer, R. W.;
- Wetmore, Barbara A.;
- Sipes, Nisha S.;
- Gilbert, Jon;
- Franz, Briana;
- Thomas, Russell S.;
- Wambaugh, John F.
Publication type:
Article
Empirical models for anatomical and physiological changes in a human mother and fetus during pregnancy and gestation.
Published in:
PLoS ONE, 2019, v. 14, n. 5, p. 1, doi. 10.1371/journal.pone.0215906
By:
- Kapraun, Dustin F.;
- Wambaugh, John F.;
- Setzer, R. Woodrow;
- Judson, Richard S.
Publication type:
Article
Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization.
Published in:
Toxicological Sciences, 2019, v. 172, n. 2, p. 235, doi. 10.1093/toxsci/kfz205
By:
- Wambaugh, John F;
- Wetmore, Barbara A;
- Ring, Caroline L;
- Nicolas, Chantel I;
- Pearce, Robert G;
- Honda, Gregory S;
- Dinallo, Roger;
- Angus, Derek;
- Gilbert, Jon;
- Sierra, Teresa;
- Badrinarayanan, Akshay;
- Snodgrass, Bradley;
- Brockman, Adam;
- Strock, Chris;
- Setzer, R Woodrow;
- Thomas, Russell S
Publication type:
Article
Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics.
Published in:
Toxicological Sciences, 2018, v. 163, n. 1, p. 152, doi. 10.1093/toxsci/kfy020
By:
- Wambaugh, John F;
- Hughes, Michael F;
- Ring, Caroline L;
- MacMillan, Denise K;
- Ford, Jermaine;
- Fennell, Timothy R;
- Black, Sherry R;
- Snyder, Rodney W;
- Sipes, Nisha S;
- Wetmore, Barbara A
Publication type:
Article
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.
Published in:
Toxicological Sciences, 2015, v. 148, n. 1, p. 121, doi. 10.1093/toxsci/kfv171
By:
- Wetmore, Barbara A.;
- Wambaugh, John F.;
- Allen, Brittany;
- Ferguson, Stephen S.;
- Sochaski, Mark A.;
- Setzer, R. Woodrow;
- Houck, Keith A.;
- Strope, Cory L.;
- Cantwell, Katherine;
- Judson, Richard S.;
- LeCluyse, Edward;
- Clewell, Harvey J.;
- Thomas, Russell S.;
- Andersen, Melvin E.
Publication type:
Article
Toxicokinetic Triage for Environmental Chemicals.
Published in:
Toxicological Sciences, 2015, v. 147, n. 1, p. 55, doi. 10.1093/toxsci/kfv118
By:
- Wambaugh, John F.;
- Wetmore, Barbara A.;
- Pearce, Robert;
- Strope, Cory;
- Goldsmith, Rocky;
- Sluka, James P.;
- Sedykh, Alexander;
- Tropsha, Alex;
- Bosgra, Sieto;
- Shah, Imran;
- Judson, Richard;
- Thomas, Russell S.;
- Setzer, R. Woodrow
Publication type:
Article
Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing.
Published in:
Toxicological Sciences, 2014, v. 142, n. 1, p. 210, doi. 10.1093/toxsci/kfu169
By:
- Wetmore, Barbara A.;
- Allen, Brittany;
- Clewell III, Harvey J.;
- Parker, Timothy;
- Wambaugh, John F.;
- Almond, Lisa M.;
- Sochaski, Mark A.;
- Thomas, Russell S.
Publication type:
Article
Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate.
Published in:
Toxicological Sciences, 2013, v. 136, n. 2, p. 308, doi. 10.1093/toxsci/kft204
By:
- Wambaugh, John F.;
- Setzer, R. Woodrow;
- Pitruzzello, Ann M.;
- Liu, Jie;
- Reif, David M.;
- Kleinstreuer, Nicole C.;
- Wang, Nina Ching Y.;
- Sipes, Nisha;
- Martin, Matthew;
- Das, Kaberi;
- DeWitt, Jamie C.;
- Strynar, Mark;
- Judson, Richard;
- Houck, Keith A.;
- Lau, Christopher
Publication type:
Article
Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays.
Published in:
Toxicological Sciences, 2013, v. 132, n. 2, p. 327, doi. 10.1093/toxsci/kft012
By:
- Wetmore, Barbara A.;
- Wambaugh, John F.;
- Ferguson, Stephen S.;
- Li, Lili;
- Clewell, Harvey J.;
- Judson, Richard S.;
- Freeman, Kimberly;
- Bao, Wenjun;
- Sochaski, Mark A.;
- Chu, Tzu-Ming;
- Black, Michael B.;
- Healy, Eric;
- Allen, Brittany;
- Andersen, Melvin E.;
- Wolfinger, Russell D.;
- Thomas, Russell S.
Publication type:
Article
Response to “Accurate Risk-Based Chemical Screening Relies on Robust Exposure Estimates”.
Published in:
Toxicological Sciences, 2012, v. 128, n. 1, p. 297, doi. 10.1093/toxsci/kfs144
By:
- Wetmore, Barbara A.;
- Wambaugh, John F.;
- Ferguson, Stephen S.;
- Sochaski, Mark A.;
- Rotroff, Daniel M.;
- Freeman, Kimberly;
- Clewell, Harvey J.;
- Dix, David J.;
- Andersen, Melvin E.;
- Houck, Keith A.;
- Allen, Brittany;
- Judson, Richard S.;
- Singh, Reetu;
- Kavlock, Robert J.;
- Richard, Ann M.;
- Thomas, Russell S.
Publication type:
Article
Physiologically Based Pharmacokinetic Model Use in Risk Assessment—Why Being Published Is Not Enough.
Published in:
Toxicological Sciences, 2012, v. 126, n. 1, p. 5, doi. 10.1093/toxsci/kfr295
By:
- McLanahan, Eva D.;
- El-Masri, Hisham A.;
- Sweeney, Lisa M.;
- Kopylev, Leonid Y.;
- Clewell, Harvey J.;
- Wambaugh, John F.;
- Schlosser, P. M.
Publication type:
Article
Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment.
Published in:
Toxicological Sciences, 2012, v. 125, n. 1, p. 157, doi. 10.1093/toxsci/kfr254
By:
- Wetmore, Barbara A.;
- Wambaugh, John F.;
- Ferguson, Stephen S.;
- Sochaski, Mark A.;
- Rotroff, Daniel M.;
- Freeman, Kimberly;
- Clewell, Harvey J.;
- Dix, David J.;
- Andersen, Melvin E.;
- Houck, Keith A.;
- Allen, Brittany;
- Judson, Richard S.;
- Singh, Reetu;
- Kavlock, Robert J.;
- Richard, Ann M.;
- Thomas, Russell S.
Publication type:
Article
Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening.
Published in:
Toxicological Sciences, 2010, v. 117, n. 2, p. 348, doi. 10.1093/toxsci/kfq220
By:
- Rotroff, Daniel M.;
- Wetmore, Barbara A.;
- Dix, David J.;
- Ferguson, Stephen S.;
- Clewell, Harvey J.;
- Houck, Keith A.;
- LeCluyse, Edward L.;
- Andersen, Melvin E.;
- Judson, Richard S.;
- Smith, Cornelia M.;
- Sochaski, Mark A.;
- Kavlock, Robert J.;
- Boellmann, Frank;
- Martin, Matthew T.;
- Reif, David M.;
- Wambaugh, John F.;
- Thomas, Russell S.
Publication type:
Article
High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures.
Published in:
NPJ Systems Biology & Applications, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41540-020-00166-2
By:
- Franzosa, Jill A.;
- Bonzo, Jessica A.;
- Jack, John;
- Baker, Nancy C.;
- Kothiya, Parth;
- Witek, Rafal P.;
- Hurban, Patrick;
- Siferd, Stephen;
- Hester, Susan;
- Shah, Imran;
- Ferguson, Stephen S.;
- Houck, Keith A.;
- Wambaugh, John F.
Publication type:
Article

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