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- Title
Autism and Epilepsy: Exploring the Relationship Using Experimental Models.
- Authors
Stafstrom, Carl E.; Benke, Tim A.
- Abstract
The common co-occurrence of autism and epilepsy suggests that certain neurobiological mechanisms are shared between these disorders. In particular, the profusion of novel genetic mutations being discovered in autism and epilepsy points to abnormalities in synapse formation and function that alter the balance between neuronal excitation and inhibition. Animal models can be informative in sorting out the medical and behavioral complexities in autism and epilepsy and the relationship between them. As mechanistic information accrues, it is anticipated that mutation- and pathway-specific targeted treatments can be developed.
- Subjects
EPILEPSY; AUTISM spectrum disorders; DENDRITIC spines; NEUROBIOLOGY; HUMAN genetics
- Publication
Epilepsy Currents, 2015, Vol 15, Issue 4, p206
- ISSN
1535-7597
- Publication type
Article
- DOI
10.5698/1535-7511-15.4.206