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- Title
White-light-induced synthesis of injectable alginate-based composite hydrogels for rapid hemostasis.
- Authors
Zhang, Meng-De; Huang, Xing; Li, Zhao; Song, Wei; Kong, Yi; Zhang, Chao; Liang, Li-Ting; Huang, Yu-Yan; Tan, Ya-Xin; Feng, Yu; Liu, Qing-Hua; Zhao, Yu-Xia; Fu, Xiao-Bing; Huang, Sha
- Abstract
Factors affecting the hemostatic efficiency of alginate compound hydrogel were mainly proportion of hydrogel components, intensity of light source, crosslinking time, etc. In summary, our study provided a new photoinitiator system Eosin Y/NPG, which was currently the most efficient white light photoinitiator commonly used, and an injectable photo-crosslinkable hydrogel AEC with good biocompability, which was proved to be a promising strategy for rapid hemorrhage control. Keywords: Photoinitiator; Photopolymerization; Alginate; Hydrogel; Hemostasis EN Photoinitiator Photopolymerization Alginate Hydrogel Hemostasis 1 5 5 10/19/23 20231017 NES 231017 Meng-De Zhang, Xing Huang and Zhao Li contributed equally to this work. Hence, we report a biocompatible and injectable composite hydrogel methacrylate alginate (Alg-AEMA)-based Eosin Y/N-phenylglycine (NPG)-initiated composite hydrogel (AEC) composed of photocrosslinkable alginate, viscosity modifiers and novel white light photoinitiator, namely Eosin Y/NPG system, for instant hemorrhage control.
- Subjects
ALGINATES; SODIUM alginate; HEMOSTASIS; HYDROGELS; SODIUM carboxymethyl cellulose; HYDROCOLLOID surgical dressings; BLOOD coagulation
- Publication
Military Medical Research, 2023, Vol 10, Issue 1, p1
- ISSN
2095-7467
- Publication type
Article
- DOI
10.1186/s40779-023-00483-7