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- Title
Changes in the expression of meteorin-like (METRNL), irisin (FNDC5), and uncoupling proteins (UCPs) after bariatric surgery.
- Authors
Jamal, Mohammad H.; AlOtaibi, Fatemah; Dsouza, Carol; Al‐Sabah, Suleiman; Al‐Khaledi, Ghanim; Al‐Ali, Waleed; Ali, Hamad; Cherian, Preethi; Al‐Khairi, Irina; Devarajan, Sriraman; Abu‐Farha, Mohamed; Al‐Mulla, Fahd; Abubaker, Jehad; Al-Sabah, Suleiman; Al-Khaledi, Ghanim; Al-Ali, Waleed; Al-Khairi, Irina; Abu-Farha, Mohamed; Al-Mulla, Fahd
- Abstract
<bold>Objective: </bold>Bariatric surgery is currently the most effective treatment for severe obesity. This study aims to investigate the changes in expression levels of meteorin-like protein (METRNL), irisin (FNDC5), and uncoupling proteins (UCP) 1/2/3 following bariatric surgery to understand their involvement in enhancing metabolism after surgery.<bold>Method: </bold>A total of 40 participants were enrolled in this interventional study, 20 with obesity BMI ≥ 35 kg/m2 and 20 with BMI ≤ 25 kg/m2 . Bariatric surgery (laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass) was performed. The levels of various molecules of interest were analyzed before and after surgery.<bold>Results: </bold>Gene expression analysis revealed significantly higher levels of METRNL, UCP1, and UCP3 in individuals with obesity when compared with healthy individuals before surgery (p < 0.05). Gene expression levels of METRNL and UCP2 showed a significant increase after bariatric surgery (p < 0.05). METRNL plasma level was significantly higher in individuals with obesity before surgery (mean [SEM], 55,222.6 [1,421.1] pg/mL, p = 0.0319), as well as at 6 and 12 months (57,537.3 [1,303.9] pg/mL, p = 0.0005; 59,334.9 [1,214.3] pg/mL, p < 0.0001) after surgery.<bold>Conclusion: </bold>The changes in the levels of various molecules of interest support their possible involvement in the inflammatory and thermogenic responses following bariatric surgery.
- Subjects
FIBRONECTINS; OBESITY; BARIATRIC surgery; MORBID obesity; GASTRECTOMY; GASTRIC bypass
- Publication
Obesity (19307381), 2022, Vol 30, Issue 8, p1629
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.23473