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- Title
The proposed modification of TNM staging and therapeutic strategy for skip metastasis in papillary thyroid carcinoma: A multicenter retrospective cohort study.
- Authors
Yang, Zheyu; Heng, Yu; Zhao, Qiwu; Hao, Ding; Tao, Lei; Deng, Xiaxing; Cai, Wei; Qiu, Weihua
- Abstract
Background: Skip metastasis is a special type of lateral lymph node metastasis, which is not classified definitely by the eighth edition of the AJCC TNM staging system. The aim of the research was to study the prognosis of skip metastasis in PTC patients, and carry out a more appropriate N staging for skip metastasis. Methods: Study subjects were 3167 patients with papillary thyroid carcinoma (PTC), who underwent thyroidectomy at three clinical centers from 2016 to 2019. We identified two well‐balanced cohorts matched on the basis of propensity score. Results: During a median follow‐up of 42 months, recurrence occurred in 68 (4.3%) patients with lymph node metastasis. 34 cases recurred in 1120 patients with central lymph node metastasis (N1a), and 34 recurred in 461 patients with lateral lymph node metastasis (N1b), among which 73 patients were diagnosis with skip metastasis. The RFS of N1a was significantly lower than that of N1b (p < 0.001). After propensity‐score matching, recurrence rate was significantly lower in the skip metastasis group than in the LLNM group (p = 0.039), whereas the rate was similar in the skip metastasis groups and the CLNM group (p = 0.29). Conclusions: In conclusion, our study indicated that, among patients with LLNM, those with positive skip metastasis showed significantly lower recurrence, exhibiting a similar rucurrence tendency as patients with CLNM. Thus, skip metastasis could be categorized into N1a stage rather than N1b stage based on the AJCC TNM staging system. The downstaging of skip metastasis may reveal more conservative treatment strategy. Our study provided the largest number of skip metastasis cases among current studies. Our series of studies on skip metastasis have progressed step by step, from the characteristics of primary tumor site to the possible factors of skip metas occurrence leading to the correlation between skip metas and prognosis in the present study. We proposed adjustments to the current AJCC TNM staging system. We provided potential treatment strategy for skip metas in PTC patients.
- Subjects
THYROID cancer; PAPILLARY carcinoma; LYMPHATIC metastasis; METASTASIS; COHORT analysis; PROPENSITY score matching
- Publication
Cancer Medicine, 2023, Vol 12, Issue 12, p13270
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.6018