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- Title
Experimental models linking dendritic cell lineage, phenotype and function.
- Authors
Fazekas De St Groth, Barbara; L Smith, Adrian; Bosco, Julian; Sze, Daniel M-Y; Power, Carl A; Austen, Felicity I
- Abstract
Summary One of the important issues in dendritic cell (DC) biology today is how DC control the fate of T cells. Our data suggest that an important branch point in determining T cell fate is the decision between deletion and memory. We have previously hypothesized that this binary decision is determined by contact with DC derived from lymphoid- versus myeloid-restricted progenitors. However, the false attribution of CD8α expression as a reliable marker of lymphoid origin has underpinned a number of studies in which DC expressing CD8α did not induce deletion, thereby clouding the issue of whether deletion is indeed a function of lymphoid DC. By returning to basics, that is, functional testing of the progeny of lymphoid- and myeloid-restricted progenitors in vivo , we hope to provide clear evidence of the in vivo roles of lymphoid and myeloid DC subsets, independent of assumptions about the surface phenotypes they can assume.
- Subjects
DENDRITIC cells; T cells; PHENOTYPES
- Publication
Immunology & Cell Biology, 2002, Vol 80, Issue 5, p469
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1046/j.1440-1711.2002.01117.x