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- Title
Usefulness of confocal laser endomicroscopy to diagnose ulcerative colitis-associated neoplasia.
- Authors
Ohmiya, Naoki; Horiguchi, Noriyuki; Tahara, Tomomitsu; Yoshida, Dai; Yamada, Hyuga; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Shibata, Tomoyuki; Tsukamoto, Tetsuya; Kuroda, Makoto
- Abstract
Chromoendoscopy, narrow-band imaging ( NBI), and confocal laser endomicroscopy ( CLE) have been introduced in ulcerative colitis ( UC)-associated neoplasia surveillance. We aimed to determine the ability of CLE to differentiate among UC-associated neoplasia (differentiated type or undifferentiated type), sporadic adenoma, and circumscribed regenerative lesions. Of 665 patients with UC, we carried out probe-based CLE ( pCLE) on 12 patients with suspected UC-associated neoplasia in addition to magnifying chromoendoscopy with crystal violet and NBI. We compared pCLE findings with pathological diagnoses. pCLE could differentiate UC-associated differentiated cancer from other pathologies such as solitary adenoma and non-neoplastic circumscribed regenerative lesions on the basis of back-to-back orientation of crypts ( P = 0.048), and UC-associated undifferentiated cancer from other pathologies on the basis of dark trabecular architecture ( P = 0.015). Sensitivity, specificity, and accuracy of combination of back-to-back orientation of crypts and dark trabecular architecture for carcinoma or dysplasia were 100%, 83%, and 92%, respectively. In vivo microscopic observation with pCLE was helpful to evaluate the suspected UC-associated neoplasia.
- Subjects
ENDOSCOPY; ULCERATIVE colitis diagnosis; ULCERATIVE colitis; COLITIS treatment; PATHOLOGY
- Publication
Digestive Endoscopy, 2017, Vol 29, Issue 5, p626
- ISSN
0915-5635
- Publication type
Article
- DOI
10.1111/den.12853