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- Title
Therapeutic Bayesian monitoring of sunitinib in two patients with impaired absorption or elimination.
- Authors
Leenhardt, Fanny; Viala, Marie; Tosi, Diego; Samalin‐Scalzi, Emmanuelle; Evrard, Alexandre; Mbatchi, Litaty C.
- Abstract
What is known and Objective: Sunitinib pharmacokinetics can be influenced by the physio‐pathological conditions of individual patients. Therapeutic drug monitoring (TDM) helps to optimize efficacy and reduce the risk of adverse effects. We report on the use of Bayesian analysis to optimize sunitinib blood levels. Case Summary: We describe two patients with risk of sunitinib pharmacokinetic variability due to gastrectomy and ongoing haemodialysis, respectively. TDM and Bayesian estimation allowed maintaining their sunitinib pharmacokinetic profiles within the usual limits. What is new and conclusion: Our analysis showed that Bayesian analysis can be successfully applied for real‐time TDM to optimize sunitinib blood levels in patients with major comorbidities.
- Subjects
MALABSORPTION syndromes; GASTRECTOMY; INTESTINAL absorption; DRUG monitoring; HEMODIALYSIS; STATISTICAL models; COMORBIDITY
- Publication
Journal of Clinical Pharmacy & Therapeutics, 2021, Vol 46, Issue 4, p1182
- ISSN
0269-4727
- Publication type
Article
- DOI
10.1111/jcpt.13424