We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The role of basic nutritional research in pediatric liver disease: An historical perspective.
- Authors
Cleghorn, Geoffrey
- Abstract
The advent of liver transplantation for end-stage liver disease (ESLD) in children has necessitated a major rethink in the preoperative preparation and management from simple palliative care to active directed intervention. This is particularly evident in the approach to the nutritional care of these patients with the historical understanding of the nutritional pertubations in ESLD being described from a single pediatric liver transplant center. ESLD in children is a hypermetabolic process adversely affecting nutritional status, metabolic, and non-metabolic body compartments. There is a complex dynamic process affecting metabolic activity within the metabolically active body cell mass, as well as lipid oxidation during fasting and at rest, with other factors operating in conjunction with daily activities. We have proposed that immediately ingested nutrients are a more important source of energy in patients with ESLD than in healthy children, among whom energy may be stored in various body compartments.
- Subjects
LIVER diseases; HEPATITIS in children; PEDIATRIC gastroenterology; VIRAL hepatitis in children; NEONATAL hepatitis; JUVENILE diseases
- Publication
Journal of Gastroenterology & Hepatology, 2009, Vol 24, pS93
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/j.1440-1746.2009.06078.x