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- Title
Stairs instead of elevators at the workplace decreases PCSK9 levels in a healthy population.
- Authors
Kamani, Christel H.; Gencer, Baris; Montecucco, Fabrizio; Courvoisier, Delphine; Vuilleumier, Nicolas; Meyer, Philippe; Mach, François
- Abstract
Backgound Regular physical activity is recommended to lower low-density lipoprotein cholesterol ( LDL-C) in a healthy population. Inhibition of proprotein convertase subtilisin/kexin type 9 ( PCSK9) was shown to reduce ( LDL-C) levels; however, the impact of physical exercise on PCSK9 levels remains unclear. Materials and methods We used data from 67 healthy hospital employees who participated in a 6-month intervention promoting active use of stairs instead of elevators during 3 months, followed by 3 months without recommendation. We confirmed the degree of physical activity with estimated aerobic capacity ( VO2 max) and measured serum PCSK9 levels at baseline, 3 and 6 month. Using a multilevel regression model, we analysed changes of PCSK9 levels over time adjusting for age, gender, aerobic capacity, baseline LDL-C, and LDL-C and body mass index ( BMI) changes. Results At baseline, PCSK9 levels were associated with higher aerobic capacity ( P-value = 0·024). At 3 months, we observed a significant decrease in mean PCSK9 levels from 403·6 to 324·3 ng/mL ( P-value = 0·001), as well a significant decrease in mean LDL-C levels from 3·5 to 3·3 mM ( P-value = 0·01). During this period, mean aerobic capacity ( VO2 max) increased from 37·0 to 40·4 mL/kg/min ( P-value < 0·001). Physical activity was independently associated with a decrease in PCSK9 levels after adjustment for age, gender, baseline aerobic capacity, and LDL-C and BMI changes. Conclusion Daily physical activity at the work place is independently associated with a decrease in PCSK9 levels over time.
- Subjects
LOW density lipoproteins; SUBTILISINS; PROPROTEIN convertases; EXERCISE physiology; BODY mass index; AEROBIC capacity
- Publication
European Journal of Clinical Investigation, 2015, Vol 45, Issue 10, p1017
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.12480