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- Title
Effect of Fluoride Toothpaste Containing Nano-Sized Sodium Hexametaphosphate on Enamel Remineralization: An in situ Study.
- Authors
Danelon, Marcelle; Garcia, Luhana G.; Pessan, Juliano P.; Passarinho, Amanda; Camargo, Emerson R.; Delbem, Alberto C.B.; Garcia, Luhana G; Pessan, Juliano P; Camargo, Emerson R; Delbem, Alberto C B
- Abstract
<bold>Objective: </bold>To evaluate the remineralizing potential of a conventional toothpaste (1,100 ppm F) supplemented with nano-sized sodium hexametaphosphate (HMPnano) in artificial caries lesions in situ.<bold>Design: </bold>This double-blinded crossed study was performed in 4 phases of 3 days each. Twelve subjects used palatal appliances containing 4 bovine enamel blocks with artificial caries lesions. Volunteers were randomly assigned into the following treatment groups: no F/HMP/HMPnano (Placebo); 1,100 ppm F (1100F); 1100F plus 0.5% micrometric HMP (1100F/HMP) and 1100F plus 0.5% nano-sized HMP (1100F/HMPnano). Volunteers were instructed to brush their natural teeth with the palatal appliances in the mouth for 1 min (3 times/day), so that blocks were treated with natural slurries of toothpastes. After each phase, surface hardness post-remineralization (SH2), integrated recovery of subsurface hardness (ΔIHR), integrated mineral recovery (ΔIMR) and enamel F concentration were determined. Data were submitted to analysis of variance and Student-Newman-Keuls' test (p < 0.001).<bold>Results: </bold>Enamel surface became 42% harder when treated with 1100F/HMPnano in comparison with 1100F (p < 0.001). Treatment with 1100F/HMP and 1100F/HMPnano promoted an increase of ∼23 and ∼87%, respectively, in ΔIHR when compared to 1100F (p < 0.001). In addition, ΔIMR for the 1100F/HMPnano was ∼75 and ∼33% higher when compared to 1100F and 1100F/HMP respectively (p < 0.001). Enamel F uptake was similar among all groups except for the placebo (p < 0.001).<bold>Conclusion: </bold>The addition of 0.5% HMPnano to a conventional fluoride toothpaste was able to promote an additional remineralizing effect of artificial caries lesions.
- Subjects
TOOTHPASTE; FLUORIDES; DENTAL enamel; REMINERALIZATION (Teeth); SODIUM phosphates; ANIMAL experimentation; CATTLE; COMPARATIVE studies; DENTIFRICES; RESEARCH methodology; MEDICAL cooperation; NANOPARTICLES; PHOSPHATES; PHYSICS; RESEARCH; EVALUATION research; CARIOSTATIC agents
- Publication
Caries Research, 2019, Vol 53, Issue 3, p260
- ISSN
0008-6568
- Publication type
journal article
- DOI
10.1159/000491555