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- Title
Age, metabolic control and type of insulin regime influences health-related quality of life in children and adolescents with type 1 diabetes mellitus.
- Authors
Wagner, Verena M.; Müller-Godeffroy, Esther; Von Sengbusch, Simone; Häger, Stefan; Thyen, Ute; Müller-Godeffroy, Esther; Häger, Stefan
- Abstract
<bold>Unlabelled: </bold>The effects of illness and treatment of diabetes mellitus extend beyond medical outcomes. We therefore evaluated health-related quality of life (HRQOL) in children (aged 8-12 years) and adolescents (aged 13-16 years) with type 1 diabetes to compare their results with healthy peers and to identify HRQOL determinants. A total of 68 children and adolescents from a tertiary care clinic which specialises in the management of diabetes, completed the generic KINDL-R questionnaire. This instrument for children and adolescents has six dimensions and an additional module assessing condition-related HRQOL. Overall, the HRQOL was not different between patients with type 1 diabetes and healthy controls. In some areas, children and adolescents with diabetes reported a better HRQOL compared to healthy peers: adolescents reported better psychological well-being (P < 0.05) and children higher levels of well-being in the school domain (P < 0.05). In general, children reported a better HRQOL (P < 0.05) than adolescents with type 1 diabetes confirming age-related differences in HRQOL in the general population. Lower HbA1c (<8%) and intensified insulin therapy (>3 injections/day) were associated with a better HRQOL in different domains (P < 0.05). The subscale "chronic illness" showed a better HRQOL (P < 0.001) in children and adolescents with diabetes compared to age-matched controls with other chronic conditions.<bold>Conclusion: </bold>Children and adolescents from a paediatric department specialising in diabetes management report good health-related quality of life. Younger age, good metabolic control and intensified insulin therapy are associated with a better health-related quality of life. Dimensions of health-related quality of life appear to play different roles at different ages, emphasising the importance of the multidimensional health-related quality of life concept and the value of age-appropriate self-reports.
- Subjects
DIABETES; DIABETES in children; DIABETES in adolescence; QUALITY of life; INSULIN therapy; SUBCUTANEOUS injections; AGE distribution; BLOOD sugar; COMPARATIVE studies; GLYCOSYLATED hemoglobin; HYPOGLYCEMIC agents; INSULIN; TYPE 1 diabetes; RESEARCH methodology; MEDICAL cooperation; PUBLIC health surveillance; QUESTIONNAIRES; RESEARCH; EVALUATION research; CASE-control method
- Publication
European Journal of Pediatrics, 2005, Vol 164, Issue 8, p491
- ISSN
0340-6199
- Publication type
journal article
- DOI
10.1007/s00431-005-1681-4