We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Late Effects of Anticancer Therapy after Childhood Wilm's Tumor: The Role of Diastolic Function and Ambulatory Blood Pressure Monitoring.
- Authors
Elli, Murat; Sungur, Metin; Genç, Gürkan; Ayyıldız, Pelin; Dağdemir, Ayhan; Güçlü Pınarlı, Faruk; Acar, Sabri
- Abstract
Objective Wilms' tumor, or nephroblastoma, is the most common primary malignant renal tumor of childhood. The excellent outcome now expected for most children with this tumor is attributed to the combination of effective adjuvant chemotherapy, improved surgical and anesthetic techniques and also the radiosensitivity of the tumor. The numerous organ systems are subject to the late effects of anticancer therapy. The aim of this study was to investigate the blood pressure profile and ambulatory blood pressure monitoring, and also cardiac diastolic functions and pulmonary venous flow in 25 children with unilateral Wilms' tumor in remission. Methods The patient group consists of 25 patients who successfully completed anticancer treatment for unilateral Wilms' tumor. Thirty-three age-, weight- and height-matched healthy children were considered as a control group for an echocardiographic study. Also, 20 age-, weight- and height-matched healthy children were considered as a control group for the ambulatory blood pressure monitoring study. Results In our study, 24 h, daytime and night-time systolic blood pressure and night-time diastolic blood pressure measurements were found to be significantly increased in the patient group compared with healthy children. We detected diastolic filling pattern abnormalities. We also found increase in pulmonary venous flow (systolic and diastolic) in Wilms' tumor group. Conclusions We suggest the regular follow-up of survivors of Wilms' tumor for care and prevention of cardiovascular diseases.
- Publication
Japanese Journal of Clinical Oncology, 2013, Vol 43, Issue 10, p1004
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyt105