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- Title
Antiemetic Efficacy of Granisetron: a Randomized Crossover Study in Patients Receiving Cisplatin-containing Intraarterial Chemotherapy.
- Authors
Uchida, Katsunori; Akaza, Hideyuki; Hattori, Kazunori; Noguchi, Ryosuke; Kondo, Fukuji; Ishikawa, Satoru; Ohtani, Mikinobu; Hinotsu, Shiro; Koiso, Kenkichi
- Abstract
Background: Cisplatin (CDDP) is one of the most active chemotherapeutic agents but is among the most emetogenic drugs. The emetic side-effects of CDDP-containing intraarterial chemotherapy have not been evaluated in a prospective randomized trial and the efficacy of serotonin antagonists in preventing the emesis associated with this method of CDDP administration has not been assessed.Methods: CDDP 50 mg/m2 and methotrexate 30 mg/m2 were administered every 3 weeks through intraarterial catheters placed in the bilateral internal iliac arteries. Patients were classified into two groups: granisetron treatment group (group G) and no treatment group (group NG) with the first course of chemotherapy, crossing over with the second course. The patients in group G received granisetron 40 µg/kg by intravenous infusion.Results: Although intraarterial CDDP administration produced less emesis than intravenous CDDP administration, at the same concentration, gastrointestinal toxicity is still the most unpleasant side-effect for patients. Granisetron administration significantly reduced nausea and vomiting during the acute emetic phase (an evaluation of treatment as very effective and effective was made in 89% in group G and 33% in group NG (P< 0.001). Complete control of emesis was achieved in 68 and 18% of patients in groups G and NG, respectively (P< 0.0001).Conclusion: A single prophylactic infusion of granisetron was effective in preventing the nausea and vomiting associated with intraarterial CDDP-containing therapy.
- Publication
Japanese Journal of Clinical Oncology, 1999, Vol 29, Issue 2, p87
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/29.2.87