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- Title
RELATIONS BETWEEN ASTHMA AND OBESITY: AN ANALYSIS OF MULTIPLE FACTORS.
- Authors
Nabuco de Oliveira Madeira, Leticia; Neves Bordallo, Maria Alice; Antonio Borges, Marcos; José Lopes, Agnaldo; Rey Madeira, Isabel; Chigres Kuschnir, Fábio
- Abstract
Objective: Asthma and obesity are prevalent and interrelated diseases. In the pediatric population, the effect of systemic inflammation associated to obesity, leading to inflammation of the airways, is currently controversial. Our aim was to compare inflammatory, clinical and spirometric patterns between children with asthma and obesity and those within the normal weight status range. Methods: A total of 79 boys and girls from 6 to 10 years old were selected and divided into four groups: obese asthmatics, nonobese asthmatics, obese non-asthmatics, and non-obese nonasthmatics. In addition to collecting clinical and anthropometric data, all children underwent spirometry and skin prick tests for inhalant allergens. Blood samples for measurement of cytokines and adipokines were also collected. Results: Obese asthmatics had significantly worse control of asthma than non-obese asthmatics (OR 4.9; 95%CI 1.1–22.1), regardless of sex, physical activity and atopy. No differences in spirometry, Th1 and Th2 cytokines and adipokines levels were observed among the four groups. The prick tests were positive in 81.8 and 80% of non-obese asthmatics and obese asthmatics, respectively. Conclusions: The degree of control of asthma was significantly lower in the obese group, regardless of the findings of no differences in spirometry. Extra-pulmonary factors could be responsible for this symptomatic profile. High positivity of skin test in both groups, which is considered a good marker of atopy, shows a preponderant atopic component in the genesis of asthma, both in children with obesity and in those within the normal weight status.
- Subjects
ATOPY; FACTOR analysis; CHILDHOOD obesity; ASTHMA; ASTHMA in children; OBESITY
- Publication
Revista Paulista de Pediatria, 2021, Vol 39, p1
- ISSN
0103-0582
- Publication type
Article
- DOI
10.1590/1984-0462/2021/39/2019405