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- Title
The role of surgery in high risk and advanced prostate cancer: A narrative review.
- Authors
Dayan Roy, Chloe Sheila; Sachdeva, Ashwin; Kandaswamy, Gokul Vignesh; Rai, Bhavan Prasad
- Abstract
Patients with high-risk and advanced prostate cancer require safe and efficacious therapies likely to offer a survival advantage while minimizing the treatment-related toxicities. Improvements in the surgical technology, diagnostic modalities, radiological staging, and risk stratification have made surgery for high-risk and advanced prostate cancer a safe and feasible option. In this review, we outline the role of radical prostatectomy in high-risk localized, locally advanced, and metastatic prostate cancer. We overview available data evaluating the use of surgery in the context of a multi-modal approach and highlight ongoing trials in this area. Furthermore, the role of surgery as a non-systemic modality for metastasis-directed therapy (MDT) is also described. Emerging imaging modalities enabling more accurate staging and longer follow-up of clinical trials for prognostic endpoints are anticipated to help identify patient cohorts and treatment strategies, where the use of surgical treatments is likely to provide oncological benefits and acceptable toxicity.
- Subjects
DIAGNOSTIC imaging; PATIENT aftercare; METASTASIS; PROSTATE tumors; PROSTATECTOMY; RISK assessment; TUMOR classification; DISEASE risk factors
- Publication
Turkish Journal of Urology, 2021, Vol 47, pS56
- ISSN
1300-5804
- Publication type
Article
- DOI
10.5152/tud.2020.20475