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- Title
Patch/plaque mycosis-fungoides-like presentations of DUSP22-translocated T-cell lymphomas.
- Authors
Runge, John S.; Novice, Madison L.; Briones, Naomi; Williams, Kiyanna; Lowe, Lori; Boyer, Daniel F.; Wilcox, Ryan A.; Tejasvi, Trilokraj; Hristov, Alexandra C.
- Abstract
The DUSP22-IRF4 gene rearrangement results in downregulation of DUSP22, a presumed tumor suppressor in T-cell lymphomagenesis. It has been described in some cases of primary cutaneous and systemic anaplastic large-cell lymphoma, lymphomatoid papulosis, and transformed mycosis fungoides. Here we describe two patients with clinical lesions resembling patch/plaque mycosis fungoides that did not meet WHO criteria for large-cell transformation on histopathology yet showed a DUSP22 translocation. One patient who had a history of systemic anaplastic large-cell lymphoma with DUSP22 translocation presented with cutaneous involvement by his systemic lymphoma along with lymphomatoid papulosis and mycosis-fungoides-like lesions, all showing an identical immunophenotype and T-cell clone. These cases expand the spectrum of DUSP22-rearranged lymphomas to include mycosisfungoides-like presentations without large-cell transformation.
- Subjects
CD30 antigen; ANAPLASTIC large-cell lymphoma; LYMPHOMAS; MYCOSIS fungoides; T cells; GENE rearrangement; CHROMOSOMAL translocation
- Publication
Journal of Cutaneous Pathology, 2022, Vol 49, Issue 3, p299
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/cup.14156