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- Title
Chiral drug fluorometry based on a calix[6]arene/molecularly imprinted polymer double recognition element grafted on nano-C-dots/Ir/Au.
- Authors
Li, Shuhuai; Pang, Chaohai; Ma, Xionghui; Zhao, Min; Li, Haibo; Wang, Mingyue; Li, Jianping; Luo, Jinhui
- Abstract
A luminescent double recognition nanoprobe is described as a new strategy for the selective determination of chiral molecules. C-dots/Ir/Au fluorescent nanoparticles, synthesised under hydrothermal conditions, are used as a high-performance probe in combination with a molecularly imprinted polymer (MIP) and calix[6]arene as a double recognition element. Thiolated calix[6]arene is grafted on C-dots/Ir/Au as the first recognition element, which then forms a host–guest complex with the target molecule levodopa (L-DOPA). Subsequently, an MIP is prepared on the C-dots/Ir/Au (MIP/C-dots/Ir/Au) by chemical polymerisation. After the removal of L-DOPA, double recognition imprinting cavities are formed. The fluorescence intensity at 478 nm of the nanoprobe is effectively quenched by adsorption of L-DOPA on MIP/C-dots/Ir/Au, which provides a method for L-DOPA determination. Owing to the double recognition strategy, this method has excellent selectivity which can effectively avoid interference from enantiomer D-DOPA, and a imprinting factor of 7.1 is obtained for L-DOPA. This accurate and reliable method, with a wide linear range (5 × 10−10 to 1.2 × 10−7 mol L−1) and a low limit of detection (1.45 × 10−10 mol L−1), was successfully applied to the determination of L-DOPA in real samples, giving standard recoveries of 89.7–110.0%. Thus, the proposed sensing method provides a viable approach for the determination of a single enantiomer.
- Subjects
MOLECULAR imprinting; IMPRINTED polymers; CHIRAL drugs; FLUORIMETRY; DOPA; NAMED-entity recognition; NANOPARTICLES
- Publication
Microchimica Acta, 2020, Vol 187, Issue 7, p1
- ISSN
0026-3672
- Publication type
Article
- DOI
10.1007/s00604-020-04356-x