We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Ergosterol Peroxide from Flowers of Erigeron annuus L. as an Anti-Atherosclerosis Agent.
- Authors
Kim, Dong-Hyun; Jung, Sung; Chung, In-Sik; Lee, Youn-Hyung; Kim, Dae-Keun; Kim, Sung-Hoon; Kwon, Byoung-Mog; Jeong, Tae-Sook; Park, Mi-Hyun; Seoung, Nak-Sul; Baek, Nam-ln
- Abstract
Flowers of Erigeron annuus L. were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH, and H2O. Repeated silica gel and ODS column chromatography of the EtOAc fraction led to the isolation of a sterol, through activity-guided fractionation, using ACAT inhibitory activity measurements. From the physico-chemical data, including NMR, MS, and IR, the chemical structure of the compound was determined to be an ergosterol peroxide (1), which has been isolated for the first time from this plant. This compound exhibited hACAT-1 and Lp-PLA2 inhibitory effects, with inhibitory values of 51.6 ± 0.9 and 51.7 ± 1.2%, at a treatment concentration of 0.23 mM.
- Publication
Archives of Pharmacal Research, 2005, Vol 28, Issue 5, p541
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02977755