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- Title
Cytotoxic activities of 6-arylamino-7-halo-5,8-quinolinediones against human tumor cell lines.
- Authors
Ryu, Chung-Kyu; Kang, Hye-Young; Yi, Yu-Jin; Lee, Chong-Ock
- Abstract
6-Arylamino-7-halo-5,8-quinolinediones ( 4a-4k, 5a-5b) were tested for in vitro cytotoxicity against human solid tumor cell lines such as A 549 (non-small cell lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), HCT-15 (colon) and XF 498 (CNS) by SRB assay. The arylamino-7-chloro-5,8-quinolinediones 4 were also evaluated for cyclin-dependent kinase (CDK2 and CDK4) inhibitory effect. Among them, the 5,8-quinolinediones 4a and 5a with 7-(4-fluorophenyl)amino group were found to be potent cytotoxic against HCT 15, SKOV-3 and XF 498, and the compounds 4f and 4i showed inhibitory activities for the CDK4.
- Publication
Archives of Pharmacal Research, 2000, Vol 23, Issue 1, p42
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02976464