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- Title
Comparative mortality of hemodialysis and peritoneal dialysis in Canada.
- Authors
Murphy, Sean W.; Foley, Robert N.; Barrett, Brendan J.; Kent, Gloria M.; Morgan, Janet; Barré, Paul; Campbell, Patricia; Fine, Adrian; Goldstein, Marc B.; Handa, S. Paul; Jindal, Kailash K.; Levin, Adeera; Mandin, Henry; Muirhead, Norman; Richardson, Robert M.A.; Parfrey, Patrick S.
- Abstract
Comparative mortality of hemodialysis and peritoneal dialysis in Canada. Background. Comparisons of mortality rates in patients on hemodialysis versus those on peritoneal dialysis have been inconsistent. We hypothesized that comorbidity has an important effect on differential survival in these two groups of patients. Methods. Eight hundred twenty-two consecutive patients at 11 Canadian institutions with irreversible renal failure had an extensive assessment of comorbid illness collected prospectively, immediately prior to starting dialysis therapy. The cohort was assembled between March 1993 and November 1994; vital status was ascertained as of January 1, 1998. Results. The mean follow-up was 24 months. Thirty-four percent of patients at baseline, 50% at three months, and 51% at six months used peritoneal dialysis. Values for a previously validated comorbidity score were higher for patients on hemodialysis at baseline (4.0 vs. 3.1, P < 0.001), three months (3.7 vs. 3.2, P = 0.001), and six months (3.6 vs. 3.2, P = 0.005). The overall mortality was 41%. The unadjusted peritoneal dialysis/hemodialysis mortality hazard ratios were 0.65 (95% CI, 0.51 to 0.83, P = 0.0005), 0.84 (95% CI, 0.66 to 1.06, P = NS), and 0.83 (95% CI, 0.64 to 1.08, P = NS) based on the modality of dialysis in use at baseline, three months, and six months, respectively. When adjusted for age, sex, diabetes, cardiac failure, myocardial infarction, peripheral vascular disease, malignancy, and acuity of renal failure, the corresponding hazard ratios were 0.79 (95% CI, 0.62 to 1.01, P = NS), 1.00 (95% CI, 0.78 to 1.28, P = NS), and 0.95 (95% CI, 0.73 to 1.24, P = NS). Adjustment for a previously validated comorbidity score resulted in hazard ratios of 0.74 (95% CI, 0.58 to 0.94, P = 0.01), 0.94 (95% CI, 0.74 to 1.19, P = NS), and 0.88 (95% CI, 0.68 to 1.13, P = NS) at baseline, three months, and six months. There was no survival advantage for either modality in any of the major subgroups defined...
- Subjects
CANADA; HEMODIALYSIS patients; PERITONEAL dialysis; MORTALITY
- Publication
Kidney International, 2000, Vol 57, Issue 4, p1720
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1046/j.1523-1755.2000.00017.x