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- Title
Screening early renal failure: Cut-off values for serum creatinine as an indicator of renal impairment.
- Authors
Couchoud, Cécile; Pozet, Nicole; Labeeuw, Michel; Pouteil-Noble, Claire
- Abstract
Screening early renal failure: Cut-off values for serum creatinine as indicator of renal impairment. Background. The aim of this study was to define cut-off values for serum creatinine as an indicator of several levels of renal impairment. Methods. To identify the suitable values, receiver operating characteristic curves were constructed based on the data of 984 laboratory assessments of renal function. The glomerular filtration rate was measured with inulin clearance. Three levels of renal impairment were analyzed. An index that gave the same weight to false positive and false negative results was used to determine the thresholds. Robustness of the results was tested using a “bootstrap” technique. Results. Considering an inulin clearance of less than 80 ml/min/1.73 m2 , the cut-off value for serum creatinine was 115 μmol/liter for men and 90 μmol/liter for women. The cut-off value for a clearance of less than 60 ml/min/1.73 m2 was 137 μmol/liter for men and 104 μmol/liter for women. For a clearance of less than 30 ml/min/1.73 m2 , the cut-off value was 177 μmol/liter for men and 146 μmol/liter for women. Conclusion. This method is useful to determine a cut-off value for serum creatinine in epidemiological studies concerning early chronic renal failure screening. The value of the glomerular filtration rate of reference and the weight of false positive and false negative results have to be adapted to the aim of the individual study design.
- Subjects
KIDNEY disease diagnosis; CREATININE
- Publication
Kidney International, 1999, Vol 55, Issue 5, p1878
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1046/j.1523-1755.1999.00411.x