We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Better understanding tumor–host interaction in head and neck cancer to improve the design and development of immunotherapeutic strategies.
- Authors
Badoual, Cécile; Sandoval, Federico; Pere, Helene; Hans, Stephane; Gey, Alain; Merillon, Nathalie; Van Ryswick, Cordelia; Quintin-Colonna, Françoise; Bruneval, Patrick; Brasnu, Daniel; Fridman, Wolf H.; Tartour, Eric
- Abstract
Head and neck cancers are heavily infiltrated by immune cells, the significance of which is complex. The natural immune response against head and neck tumors, including anti-human papillomavirus (HPV) T cells, and humoral responses has been clearly documented. However, during the course of tumor progression, co-option of the immune system by tumor cells for their own advantage and increased resistance of tumor cells to immune attack also occur. Inflammation and immune subversion to support angiogenesis are key factors promoting tumor growth. Only a better understanding of this tumor–host interaction will permit a rational design of new immunotherapeutic approaches combining immunostimulation with drugs endowed with the ability to counteract immunoevasion mechanisms. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
- Subjects
PAPILLOMAVIRUSES; CANCER cells; IMMUNE system; NEOVASCULARIZATION; IMMUNE response
- Publication
Head & Neck, 2010, Vol 32, Issue 7, p946
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21346